AviGuard™ – Pre-Affinity Impurity Clearance Resin

Flow-through purification for cleaner viral vector processing

AviGuard™ is a synthetic affinity resin designed to remove host cell proteins (HCPs), host cell DNA (hcDNA), and plasmid DNA (pDNA) from viral vector harvests prior to affinity capture. Used as a flow-through polishing or guard column, AviGuard enhances downstream efficiency, improves product quality, and protects high-value resins while preserving viral integrity.

AviGuard Features & Benefits

• Selective Impurity Removal
  Captures HCPs, hcDNA, and pDNA without binding viral products like AAV, lentivirus, or vaccines.
• Improved Capture Efficiency
  Reduces impurity competition during affinity binding, improving ligand performance and product yield.
• Extended Resin Lifetime
  Protects expensive affinity resins from fouling and overloading, increasing column reuse and cost efficiency.
• Enhanced Product Quality
  Removes impurities that can reduce viral infectivity or transduction potency, supporting therapeutic performance.
• Fully Scalable and GMP-Ready
  Operates in flow-through mode, with low backpressure and seamless integration into modern downstream processes.

Designed For

• Pre-affinity polishing of AAV, lentivirus, and other viral vector harvests
• Developers of gene therapies and vaccines needing consistent impurity control
• CDMOs and process developers aiming to streamline multi-step purification

AviGuard™ gives cell and gene therapy manufacturers the ability to clean up complex lysates, protect downstream assets, and deliver safer, more consistent viral vector products with minimal process complexity.