AvXcel™ – Serotype-Agnostic AAV Affinity Resin

Powerful, pan-serotype purification from HEK293 and Sf9 lysates

AvXcel is a synthetic affinity resin designed for efficient, serotype-agnostic purification of adeno-associated viruses (AAVs). Engineered for use with HEK293 and Sf9 expression systems, AvXcel delivers high binding capacity, excellent impurity clearance, and gentle elution to protect viral activity.

Key Features & Benefits

• Serotype-Agnostic Capture
  Synthetic ligands target conserved epitopes across all AAV clades and clones for broad utility.
• High Dynamic Binding Capacity
  DBC10% exceeds 5×10¹³ viral particles per mL of resin, enabling efficient, large-scale purification.
• Superior Impurity Clearance
  Effectively removes host cell proteins (HCPs), host cell DNA (hcDNA), and plasmid DNA (pDNA).
• Mild Elution Conditions
  Elution at ~pH 6.0 preserves AAV transduction potency and product integrity.
• Scalable, Safe, and Cost-Effective
  Fully synthetic ligands eliminate the need for recombinant protein production, reducing batch-to-batch variability and simplifying scale-up.

Designed For

• Upstream harvests from HEK293 or Sf9 systems
• Gene therapy developers seeking platform-ready, high-yield purification
• CDMOs aiming for scalable, cost-efficient AAV downstream processes

AvXcel sets a new benchmark for universal AAV capture — delivering robust performance across serotypes while preserving the bioactivity critical for clinical success.